Couple of errors:

Error 1: Required Unicode font is not installed on this system

Fix: 

Change the font in the program to something available on your system such as  Dejavu Sans or Liberation Sans.

Error 2: File or path not found

Cause:

When you navigate to your password safe and then click "Open" only the filename is returned to Password Safe and not the full path:

 Solution:

# from a terminal
# change to where  you store your password safe
$ cd ~/My\ Safes/
$ ls
pwsafe_002.ibak  pwsafe_003.ibak  pwsafe_004.ibak  pwsafe.psafe3
# create a windows path using winepath
$ winepath -w pwsafe.psafe3
Z:\home\myuser\My Safes\pwsafe.psafe3

Construct the fullpath using winepath and the name of your password safe file

"Z:\home\myuser\My Safes\pwsafe.psafe3"

Close Password Safe and restart. Now paste the path and filename into your password safe screen as shown here, enter your combination and you're good to go:

Once you have successfully opened password safe once it will have added it to the most recently used list and you can select it each time...