I just had an issue where I couldn't use the winecfg app to change my default audio driver. It seemed to be locked onto OSS and my system is ALSA.

My setup is wine-0.9.41 and Wine Doors version 0.1 on Fedora 7.

I tried using vi to change ~/.wine/user.reg

[Software\\Wine\\Drivers] 1185794426
"Audio"="oss"


But every time I changed the value to "alsa" and then launched winecfg it changed back to "oss"

The fix:

Open regedit and navigate to the registry key HKEY_CURRENT_USER\Software\Wine\Drivers and change the Audio value to "alsa"

The change seems to have stuck